Peroxisome basa. Zellweger urwere

Nhasi tinokukumbira kuti funga peroxisome ushande. Chii ukoshi vane muna keji? nesuwo kuteerera kuti chii chirwere unogona kuona uchibatsirwa organelle ichi.

Nechekare mumashoko okusuma, zviri pachena kuti peroxisomes - nayo organelles. Muchitokisi, akavapindurawo, rutivi kusimba yakagozha Mugadziri zvose dzinoitwa isu. Kunyange murume rinoumbwa masero, izvo pane guru chaizvo nhamba. Uye sero rinoumbwa zvikamu kunyange zviduku, asi vanobvumira wake kutungamirira yakazvimirira upenyu, kureva kuti ibatane nokusika ezvirevo kunzwisisa hakuna zvakakodzera. Muenzaniso uyu nyore chete-celled zvisikwa, izvo iwe zvimwe akanzwa zvipenyu zvidzidzo kuchikoro.

Tisati zvinyore uye kundorondedzera peroxisome basa, tinofanira kunzwisisa kuti chii uye sei avanoshandira.

peroxisomes

organelles izvi kuonekwa sezvo tuduku vacuoles, saizi yavo pasi 1.5 micron. Peroxisome takapoteredzwa nhete Kamudzira, uye Anopatsanura microgranules mukati, kubva womukati hwaiitwa muchitokisi yose. Tinogona kuwana mukati organelle? Pane chinoumba, zviri kunzi nucleoid. Zvakakosha kunzwisisa kuti chikamu ichi peroxisomes haina chokuita nemamiriro renyukireya kana nucleoid utachiona. Regai kunyonganisa izvi pfungwa. uye kazhinji kuti dzakaonekwa zvivako mimicking crystals nucleoid mapazi. Vari aumba kubva fibrils uye sepombi. Chinoumba organelle ichi aparadzana peroxisomes, uratoksidoza huri mukati maro. Uyu ndiwo mumwe makemikari. Zvino isu zvamaronga kuti kufunga peroxisome basa muchitokisi. Asi vasati kuti, tikanyatsoongorora chacho.

mamiriro

Zvino tichazvidudzira chii peroxisomes, mamiriro uye mashandiro (ona tafura) zvicharehwawo waongororwa nesu. Chokutanga tinofanira kupa chinooneka muchimiro patafura. Next, nyora zvakadzama marongerwo uye mashandiro peroxisomes. The tafura inogona akasikwa kubudikidza nesu, asi zvakakwana kucherechedza kuti peroxisome chizvaro uye rine nucleotide.

Matrix 15 chine peroxisome makemikari. Ngatimboonai zvimwe. Achisimbisa kukosha vavo:

• peroxidase;
• catalase;
• oksidoza;
• uratroksidaza.

Uye chii basa zvino anoita nucleotide? Basa racho dzora makemikari idzodzo. Ngatitarisei kuti muitiro rokuumba peraksisom. Ivo ichatungira kubva EPS, saka tinogona kutaura kuti nzvimbo kugadzirwa organelle ichi - a CSE. Makemikari anobudiswa mu:

• EPS;
• hyaloplasm.

Pano zvakakosha kujekesa ndechokuti Kamudzira, kunyange mutete, asi haina kupinda kunyange ions uye pasi samolecular uremu substrates. Zvino tinogona kufunga mashandiro peroxisomes. Kwokutanga organelle ichi zviri zvikuru nokuda muchitokisi.

mabasa

Peroxisome mabasa ndeinotevera:

• oxidation pamusoro Organic zvinhu;
• nemafuta asidhi oxidation;
• biosynthesis plasmalogens;
• isoprenoid biosynthesis kwemhuka;
• biosynthesis pamusoro remafuta akawandisa;
• NDR2 mapuroteni localization;
• mutemo systemic kuzvimba;
• kubatsira nedanho afemeruke iri chirimwa mumasero, uye zvichingodaro.

Iyi ndaza refu kwazvo, nekuti vamwe mabasa vasati ainyatsonzwisisa. Zvino isu kupa zvakawanda zvishoma kutaura mapuroteni usage. Zvakakosha kuziva kuti organelles izvi dzine zvikamu zvakadai:

• DNA;
• ribosome.

Saizvozvowo, puroteni usage rikaitika musimboti. Next ndiyo youhu dzomunyika hwaiitwa peroxisomes. chinoumba zvainoreva sei? By pokuita C-inouraya chiratidzo. The kutevedzana kwezviitiko kukanganiswa iri pfupi chaizvo, zvinosanganisira 3 amino asidhi residues.

The ukoshi ari zvekuchipatara kuongorora

Takurukura muzvirevo chikamu, iro basa rinoitwa nevanhu peroxisomes. Zvino zvishoma pamusoro kunotoda date kuenda organelle. Zvino isu kutaura zvishoma pamusoro chirwere rinonzi - Zellweger syndrome. Uyu chaizvo chirwere chakakomba, zviri kukonzerwa kutyora mapuroteni imupota. Somugumisiro, peroxisomes chinhu, sero uye nhengo yose padzakacherechedza mashoko rikwanise kukundikana organelles. Vanhu vanotambura zvinetso izvi vachinetseka basa dzimwe mitumbi inokosha pano dzinosanganisira:

• pfungwa;
• chiropa;
• neitsvo.

Vana vanozvarwa vaine chirwere ichi hazvigoni kurarama kwenguva refu uye vanomanikidzwa kusiya nyika yedu pashure pfupi pokugara. The chirwere Rinobatanidzwa ane mutation pamusoro organelle. Zvinogonekawo uye zvishoma ngozi siyana chirwere.