"Pyrazinamide" Mahwendefa vane bactericidal kana bacteriostatic mugumisiro Anti zvichienderana wevasungwa. mushonga basa anodzokororwa chete pasi acidic ezvinhu (ari ph pamusoro 5.6 uye pazasi). pamusoro ivhu mishonga zvinobvira kukura nemishonga, izvo zvinoderedza mikana yokushandisa mishonga nezvimwe antitubercular nevamiririri. Kugadzirira "Pyrazinamide" (mirayiridzo Chinyorwa inosimbisa izvi) zvinonyanya kubudirira kana rokuparadza tiibhii sezvo vakaona kokutanga, kurongedza caseous-utachiona hwedenda mhando tuberkulomah, caseous lymphadenitis. The mushonga lowers yokufambisa urate uye uric acid, hyperglycemia anogona kukonzera. The mushonga kubva nemudumbu anenge zvachose uye nokukurumidza kunyura. Plasma mapuroteni vasunge medicament 10-20%. Shure kweawa kana maviri pane kufadza wevasungwa mari. Mishonga iri zvakanaka richiparadzirwa pamusoro muviri zvinwiwa uye munyama, anofanira iiswe zvomukati, kusanganisira mapapu, chiropa, neitsvo uye zvikamu encapsulated tuberculous maronda. Means inopfuura kuti BBB. Muviri kunoitika muna chiropa.
umboo
Medicament "pyrazinamide" (mhinduro nyanzvi ngaadarowo) ndicho chisarudzo wokutanga pakurapa tibhii.
dosing zvaiitwa
It Vakawana kuti monotherapy hakuna inoshanda zvakakwana. Maererano neizvi zvinodhaka "pyrazinamide" mirayiridzo Chinyorwa anokurudzira kushandisa akabatana nevamwe mishonga kushingaira TB. Nokuti vakuru, kuti chipimo chemushonga ndiyo 30-35 MG / makirogiramu kamwe pazuva. Varwere yairema makirogiramu asingasviki mashanu, chipimo chemushonga ndiwo mapiritsi matatu (1,5 g). Kana gobvu ndiro makirogiramu anopfuura 50 vanofanira kutora 4 Mahwendefa. (2 g). Nokuti vana kufadza dose - 2 magiramu. The mushonga chinobviswa nezvokudya. Zvinokurudzirwa kunwa mushonga panguva chisvusvuro.
"Pyrazinamide" zvinoreva. Mirayiridzo kushandiswa. Zvokungwarira
Mishonga ovhadhozi achiita zvaidiwa yachiremba akaarayira kukonzera. Kana ukapiwa yakawanda mushonga vakachengeta kunaka migumisiro musimboti tsinga - dzungu, nomusoro uye nevamwe. manotsi nyonganyonga ari chiropa, zvichida dyspepsia. Kana muchetura dzakaratidza symptomatic kurapwa. Asati uye panguva TB kurapwa pavarwere makore 60 rinoitwa pamwedzi richiona nezvezvabuda zviratidzi ose bilirubin, AST, uric asidhi uye alt. In zvinetso chiropa inoda kubviswa zvinodhaka. In varwere cheshuga kazhinji kutanga yomuropa. Kana pamwe mishonga kutora mushonga "Rifampicin" inogona kuchengetwa hepatotoxicity. Kana revatema pamwe kushanda pakugadzirira "Probenecid" zvichida kuderera excretion uye somugumisiro, zvakawedzera toxicity. Pangava muchinjikwa-wanda ne mishonga "INH", "Ethionamide" nicotinic asidhi uye nedzimwe nzira vane makemikari mamiriro akafanana. "Pyrazinamide" mushonga (mirayiridzo kushandiswa inosimbisa izvi) Kuendererana neNzvinodikanwa kwemakore mashanu. The sezvamunoita anochengeterwa rakanamwa kavha, munzvimbo yakadzivirirwa kubva chiedza.