Collagenosis - chii ichocho? Zviratidzo, Kuongororwa uye Kurapa Kwezvirwere

Mukurapa kwemazuva ano, pane kazhinji kuongororwa kwe "collagenosis." Chii ichocho? Ichokwadi, izwi iri rinosanganisira zvirwere zvakasiyana-siyana, izvo zvinowanzofanana - zvinoshandiswa muzvibatanidza, pamwe, fibrinoid collagen zvipembenene.

Zvechokwadi, varwere vanowanikwa ne "systemic collagenosis" panic. Saka, kutanga zvakakosha kudzidza zvakawanda nezvirwere zvakadaro uye maitiro avo. Ndezvipi zvirwere zvinowanikwa muboka re collagenoses? Ndezvipi zvikonzero zvekuitika kwavo? Ndezvipi zviratidzo zvandinofanira kutarisa nazvo? Ndinokwanisa kubvisa zvirwere zvegorgen nokusingaperi here? Ndezvipi zvinotaurwa navanachiremba? Vanhu vazhinji vari kutsvaga mhinduro dzemibvunzo iyi.

Collagenosis: chii ichocho?

Izvozvo zvinoshandiswa, sezvinozivikanwa, inorudzi rwekuvaka kwemuviri. Semuenzaniso, inoumba skeleton uye ganda romunhu, masvingo emidziyo yeropa, stroma yechipfuva, uyewo anozadza zvipakati pakati pezvivako zvakasiyana. Icho chimiro chinoita zvinopfuura hafu yehutatu hwemunhu. Nhengo dzemuviri dzakagadzirisa dzinoita mabasa anokosha anoverengeka, kusanganisira trophic, kudzivirira, masangano, kutsigira uye mapurasitiki. Ndiyo zvirwere zvehutano hunobatanidza hunobatanidzwa pasi peshoko rokuti "collagenosis".

Chii ichocho? Iyi iboka rezvirwere izvo zvinowanzo zviratidzo uye nzira yekusimudzira. Zvirwere zvinokurwisana nehutachiona hwemapurisa homeostasis uye zvinofambidzana nekushanduka kwe fibrinoid mu collagen.

Mhando dzechirwere chegorgen

Mishonga yemazuva ano inonyatsozivikanwa nokuda kwekusiyana kwegorgenase. Chikamu chavo chinotarirwa pamatangiro echirwere. Semuenzaniso, kupararira kwezvirwere zvinokonzerwa nehutachiona kunogona kuve kukanganisa. Kune boka iri zvinosanganisira syndromes ya Stickler naMarfan, uyewo mucopolysaccharidosis uye osteogenesis isina kukwana. Zviratidzo zvavo, sekutonga, zvinowanikwa panguva yekuwedzera kweprauterine.

Kune zvirwere zvinowanikwa izvo zvinozviratidza pachavo mushure mekuberekwa - dzimwe nguva muhuduku kana muhucheche, uye dzimwe nguva kunyange mukukura. Iri boka revanhu vanoshungurudza rinosanganisira systemic vasculitis, scleroderma, rheumatoid arthritis, rheumatism, eosovirus fasciitis, nodular periarteritis, nezvimwe zvizhinji.

Zvinonyanya kukonzera chirwere chacho

Maitiro eC Congenital echirwere anobatanidzwa nehutachiona hwehutachiona hwemetabolism uye chimiro che collagen. Nekuwana maitiro ehutachiona, zvikonzero zvinogona kuva zvakasiyana kwazvo, uye zvidzidzo zvehutano hwekuvandudzwa kwezvirwere zvinenge zvichiri kuitika.

Masayendisiti anowanzotenda kuti kune mazita ekuberekwa kwemafiro munharaunda dzose. Asi pane zvinhu zvakawanda zvinogona kukanganisa chirwere chacho. Semuenzaniso, kazhinji chinokonzera kupinda mukati memuviri wehutachiona hwehutachiona uye hwebhakitiriya, kusanganisira causative mavhinga emumps, herpes, rubella masheya, nezvimwewo.

Zvimwe zvinokonzera zvinogona kunge zviri hormonal bursts zvinowanikwa munguva yekuyaruka, pamuviri uye kumisa kumwedzi, shure kwekubvisa pamuviri, nezvimwe. Pane zvimwe zvikonzero, pasi pesimba iyo chirwere chinowedzera. Collagenosis inogona kukonzerwa nokushungurudzika kukuru, kushungurudzika, mishonga, yakaipa hypothermia, kushorwa. Dzimwe nguva chirwere chinokura mushure mekudzivirira.

Pathogenesis yechirwere

Pasinei nezvirwere zvakasiyana-siyana zveboka iri, munenge mamiriro ose ega chirwere chinokura maererano nechirongwa chimwe chete. Pasi pesimba reizvi kana ichocho, kukurudzirwa kwemasimba ezvirwere kunowanzoitika, semugumisiro weiwo mapuroteni akawanda anogadzirwa, anobva agadzika pane serous uye synovial membranes, zvikamu zvepachiviri. Kuvapo kwezvirwere zvekudzivirira muviri kunokonzera allergen kuvhiringidza kwemasukisi. Saka, hutachiona hwemunhu hunotanga kurwisa hutachiona huno.

Mukurwisana nemamiriro ezvinhu epamusoro apa, pathomorphological changes in the tissues inowanikwa. Zvechokwadi, rudzi rumwe rwemakorgenosis rine zvimwe zvinhu. Semuenzaniso, mu scleroderma, chirongwa chekudzivirira muviri chinogadzirisa hutachiona uye zvinyorwa zviduku, uye nodular periarthritis inoratidzirwa nekuchinja mumidziyo yeropa.

Zvirwere zveCollagen: Mufananidzo uye kliniki yakawanda

Chii chinonzi chinyorwa chemakiriniki chinoratidzika? Ndezvipi zviratidzo zvinosanganisira collagenosis? Zviratidzo, zvechokwadi, zvichasiyana zvichienderana nezvakasiyana-siyana zvechirwere uye nzvimbo yekuvhiringidza. Kunyange zvakadaro, zvimwe zvinhu zvakajairika zvinogona kusiyaniswa.

Varwere vanoona kuwedzera kwekuwedzera kwekushisa kwemuviri kusvika kune digirii 38. Varwere vanongonyunyuta nezvechills uye kuputika kukuru. Iko kushaya simba uye kuderera kwehutano. Chero nemhando ipi neipi ye collagen, majosi-muscular syndrome inokura, iyo inoratidzirwa nemarwadzo akabatana, myalgia uye arthralgia. Dzimwe nguva pane zvinokonzerwa neorigic, maitiro ehurhes paganda, kurwadziwa kwepamuviri, zvinetso zvekudya.

Nodular periarteritis uye zvayo

Collagenoses yakasiyana-siyana mumasikirwo emunhu, saka zvakakosha kufunga nezvemhando dzakasiyana uye dzakanyanya. Nodular periarteritis inoratidzwa nekukundwa kwezvikamu zvitatu zveurusvingo. Inenge dzose midziyo yemuviri inobatanidzwa mukuputira.

Zviratidzo zvinotenderera pane zvipi uye zvirwere uye mitsetse zvakakanganiswa. Kana iri mubvunzo wemidziyo yeitsvo, zvino varwere kutanga kwekutambudzika kose kwekunzwa mumucheto wezasi, kuputsa kwekubuda kwemuti. Pane huwandu hwehutachiona uye kukundikana kwechirwere chinopfuurira. Apo masvingo emakamuri emakumbo anovhiringidza, murwere anowedzera kukanganisika kwepfungwa dzakasiyana-siyana. Chikamu chechina chevarwere vane nodular periarthritis vane brhchial asthma.

Systemic lupus erythematosus

Lupus erythematosus - yakaoma systemic collagenosis. Chii ichocho? Ichi chirwere, chinosangana nekukundwa kwenharaunda dzose dzesangano. Pamusoro peganda rinoratidzika sehutsvuku hwekuputika (pachiso chavo vane nzvimbo inonyanya kuonekwa mumatama uye mumhino, iyo inofanana nemapapiro ebhururuki).

Pane kukundwa kwembambo uye vhudzi, zvipembenene uye kusvibiswa kunoonekwa pane mucous membrane. Muchiratidzo chekuvhiringidza chaisanganisira zviduku zvishoma. Chirwere ichi chinopesana nekuputsika kubva pamwoyo nemapfupa ekufema. Kurapa kwepoyo uye kuonekwa kwezviratidzo zvepfungwa zvinowanikwa.

Systemic scleroderma

Scleroderma ndechimwe chirwere chisingagadziriswi umo chirwere chokuvhiringidza chinokanganisa ganda, zviduku zvinopfurikidza, mishonga yeperiipheral, mafundo nemisungo. Zviratidzo zvakajeka ndeyeganda rinoshanduka. Chokutanga, kune kuvhara kweganda. Dermis inowana para kana, asi kusiyana, mumvuri mutsvuku. Muchikamu chechipiri chechirwere, edema inova yakaoma kwazvo, ganda revarwere rinotapira uye rakaoma, spikes inoumbwa nehutachiona.

Chikamu chechitatu chinotungamirirwa ne-atrophy yezvipembenene zviduku uye zviduku. Muviri weumwe munhu anorwara wapera, minwe zvishoma nezvishoma yakasvibiswa, chiso chinowana kuonekwa kwemasikisi nekuda kwekunyangarika kwechitarisiko chechiso.

Kuongorora nzira

Nzira yekujekesa collagenosis sei? Kukundwa kwevamwe nhengo kunofambidzana nekuratidzika kwezviratidzo zvechimiro, izvo nyanzvi inotarisa panguva yekukurukura nemurwere uye kuunganidza annesnesis. Uyezve, zviitiko zvakasiyana-siyana zvebhroatori zvinoitwa. Kunyanya, ropa remunhu anorwara rinotarirwa kuvepo kwemazino asina kuvhiringidza, kureva: fibrinogen, pro-C-reactive protein, alpha-2-globulins. Chidzidzo chinoshandiswawo nokuda kwekuvapo kwezviratidzo zvekudzivirira muviri mumuviri, izvo zvakananga kune umwe neumwe chirwere.

Kakawanda kuitira kuti uongorore zvakakwana mamiriro ezverwere, biopsy inoitwa. Iyo sampuli inotorwa kubva mumatumbu emasumbu, ganda, itsvo, synovial membrane yezvibatanidzwa.

Panewo zvidzidzo zvinobatsira kubatsira kugadzirisa chirwere chakadai segorgengenosis. Kuongororwa kunosanganisira X-ray kuongororwa kwemasangano nemapfupa. Mumufananidzo, chiremba angaona maitiro ezviratidzo zvezvipembenene zvinoshandiswa, zvinosanganisira osteoporosis, articular surface change uye aseptic necrosis yavo, kuderedza masangano akabatanidzwa, nezvimwewo.

Sezvo collagenoses inowanzoperekedzwa nekukuvadzwa kune nhengo dzomukati, nzira inokosha ndeye ultrasound kuongororwa kwemuviri wepamuviri, itsvo, chirema chemoyo, moyo (Echocardiogram). Pamusoro pezvo, kombiyuta kana magnetic resonance imaging inoshandiswa kuongorora mamiriro emuviri, pamwe nekukuvadza kune nhengo dzomukati uye skeleton.

Mishonga yezvirgoni zvegrogen

Ndeapi rudzi rwehutano hunoita collagenosis inoda? Kurapa kwezvirwere zveboka iri kunofanira kunge kwakaoma. Chirongwa chekurapa chinogadzirwa mumwe nomumwe, nokuti chinoenderana nechimiro uye chikwata chekufambisa kwechirwere, kuvapo kwezvirwere zvinokonzera, nguva yemurwere.

Sezvo collagen inokonzera kuvhiringidza zvipembenene zvezvibatanidza zvishandiso zvemavara, pakutanga, varwere vanorayirwa zvinopesana nezvinokonzera zvinodhaka. Mune matanho ekutanga ekubudirira, mishonga isiri-steroid inoshanda, kunyanya iyo ine ibuprofen.

Mune zviitiko izvi, kana chirwere chichikura nokukurumidza zvikuru, glucocorticosteroid kugadzirira nemamwe maitiro anopesana-kupisa simba zvinowanikwa muhurongwa hwehutano. Sokutonga, "Prednisolone" inoshandiswa (iyo inowanikwa zuva nezuva haisi kupfuura 15 mg).

Migumisiro yakanaka inowanikwa nekurapa ne cytostatic drugs ("Azathioprine", "Cyclophophamide"). Kurapa kwakadaro kunoitwa muchiitiko apo kugamuchirwa kwe-steroid hakubvumiri kutarisira kuitika kana kuti kwakakonzera kushungurudzwa kwakaipisisa.

Kurapa kwechirwere panguva yekuwedzera kunopedzwa mumamiriro ezvinhu echipatara. Murwere anosunungurwa kubva kuchipatara mushure mekunge atokwanisa kurarama nemararamiro makuru. Zvakakosha kuti titevedzere nzira yakarurama yebasa nekuzorora, pamwe nekucherechedza chikafu, kwete chete panguva yekuwedzera, asiwo muupenyu hwose.

Zvimwe kurapwa

Ndeapi mamwe marapirwo anoda kuti collagenosis? Kurapa hakudikanwi kwete panguva yekuwedzera, asiwo panguva yehukama hune muviri. Kuti zvirambe zvishoma nezvishoma kuwedzera kwechirwere, nzira dzekuchenesa dzinoshandiswa, kunyanya hemosorption uye plasmapheresis. Vamwe varwere vanorayirwawo physiotherapy. Migumisiro yakanaka yakawanda inogona kuwanikwa kuburikidza nekubatsirwa kwemazuva ano magnetotherapy, drug electrophoresis, ultraphonophoresis.

Ne rheumatoid arthritis nedzimwe zvirwere, hutano hwekurapa huchabatsira, izvo zvichabatsira kuchengetedza kugara kwakanaka. Varwere vanorayirwa nguva dzose sanatorium kurapwa mumasangano ehutano hwakakodzera. Nezvimwe zvirwere zvegrogen, zvakanaka zvinogadzirwa ne radon, hydrogen sulphide uye kabhoni dioxide mabhati. Ichokwadi kuti chirwere chirongwa chinogadzirirwa nachiremba zvichienderana nemhando dzakasiyana dzechirwere, chizvarwa uye chimiro chomunhu anorwara.

Matanho ekudzivirira uye kutarisirwa kwevarwere

Chirwere che collagenosis (chero ipi zvayo yakasiyana-siyana) inoratidzirwa nekufambira mberi, kusingaperi. Medicamental therapy inoita kuti zvikwanise kuderedza zviratidzo zvechirwere uye kuti zvive nekuregererwa kwenguva refu kana kudarika. Kunyange zvakadaro, zvinenge zvisingakwanisi kubvisa zvachose chirwere chacho. Zvinonyanya kuipa ndiwo systemic collagenoses, iyo inowanzoguma nekugadzirwa kwepfungwa yekudzivirira kana mwoyo kusakona.

Kuwana mahomoni nemaune immunomodulator zvechokwadi zvakakosha. Asi varwere vanofanira kutarisa hutano hwavo nekuregererwa, sezvo izvi zvichabatsira kubvisa kuwedzera kwekuwedzera. Varwere vanorayirwa kuti vasave nemigumisiro yekuvhiringidza zvinhu, zvisinei kuti zvinokonzera kushungurudzika uye kukundikana kwehomoni, kana kukura kukuru kwewaini uye kunyanyisa kudurura. Kana uine chirwere chinotapukira, unoda kuona chiremba pakarepo. Foci yekusagadzikana kusingaperi inofanirawo kuve yakagadziriswa pakurapa kwakakwana.