Human interferon - biological properties

Interferon yevanhu yakawanikwa muna 1957 nemasayendisiti maviri Isaacs naLindemann. Kuvonga uku kuwanikwa, nzira itsva yekudzivirira masero evanhu kubva kuhutachiona hwehutachiona yakagadzirwa. Hush-inactivated furuwenza vanyori vevhangeri vaisungirirwa pamusoro pekukudzirwa kwekuku, kuenzanirana neCAM, uye vakawana kuti kupisa simba kwakaderedza kukura kwehutachiona hunoshanda paCIR. Chimwe chinhu chaive mu homogenate chainzi interferon, uye iyo yega yega yezvigadzirwa zvehupenyu kwemakore akawanda yakanzi yakadzivirirwa nehutachiona. Yakave yakasimbiswa kuti masero ezvitunha zvakasiyana-siyana zvevanhu nemhuka zvinoshanda sevanoparidzi vepferon. Iyo yakaumbwa inokonzerwa nemavirusi, zvishoma nezvishoma nemaabhakitiriya, pathogenic fungi, protozoa, simba remasikeni, maitiro ekugadzira mapurisa. Leukocytes inokwanisa kukonzera kupindirana kwe interferon kutanga kwemaawa 3-4 mushure mokunge hutachiona huchibatanidzwa.

Izvo zvinofanira kuonekwa kuti chiitiko chekupindira kwemavirusi chinonyatsozivikanwa kwenguva refu. Izvo zvinovakirwa pamusana pekugona kuchengetedza munhu kurwisana nechiito chechirwere chinokonzera nekubatsirwa kwezvinhu zvekusagadzikana kwemasimba, kana panguva imwe chete kana kuti yapfuura utachiona husina ngozi hunopinda mumuviri mumwechete. Chimwe chinhu chakafanana, ichocho, chiitiko chekupindira kunoonekwa pakati pezvirwere zvebhakitiriya kubva mukugadzirisa kwekubatana kwavo. Zvinonzwisisika kuti rumwe rudzi rwehutachiona hunopararira runogona kudzivisa kubereka kweimwe mhuka uye nokudaro kuchinja nzira yehutachiona hunokonzerwa nayo. Zvinoratidzwa kuti kana munhu kana mhuka inobatwa neBrucellosis, inokudzivirira kusachengetedzwa kweanthrax bacilli. Kusiyana pakati pe brucella uye tularemia mabhakitiriya inotsanangurwa. Pane chikonzero chekutenda kuti nekupindira kwebhakitiriya inhibitor inogadziriswa kudzivirira masero anogadzikana mune macroorganism, izvo zvinoita kuti zvisakanganise mamiriro ekuvapo kweimwe yezvirwere zvinorwisana.

Maererano nemazuva ano, pane marudzi matatu e- interferon (gamma-immune, fibroblast beta uye alpha-leukocyte interferon), iyo inopesana mumavambo, zvisikwa uye zvepanyama. Zvinofanira kurehwa kuti kupindira pakati pemishonga inokonzerwa nekubatanidzwa kweiyo inhibitor inokosha, inoshandiswa nemasero ehutachiona hutachiona.

Zvinoratidzwa kuti interferon yevanhu iboka rehupenyu hwehupenyu hunoenderana nehutachiona hunosimbiswa mumasero mushure mekusimudzirwa nevanoridzika zvakasiyana-siyana. Iko kusungurudzika kwe-interferon, iyo inogona kukanganisa basa rezvinyorwa zvevirusi zvakasiyana-siyana mumuviri, rinopfurikidza zvakasimba. Iyo inonyanya kunzwisiswa nezviito zve interferon kune mavairusi ane mazamu ekunze uye miromo yepidid (myxoviruses, arboviruses, virusi yepukanana), asi picornaviruses uye adenoviruses hadzina shell yakadzika uye zvinoramba zvisingakanganisi chinhu ichi. Zvisinei, kune zvimwe, apo mavairasi ane chiganda ichi, anowedzera kukurira kumabasa e interferon (herpes viruses).

Human Interferon

Izvo zvinokurudzira zvikuru zvekuumbwa kwayo zvinofungidzirwa nevakawanda kuva iko kupindira kweyucleic acid kunze kwekamuri, iyo inokanganisa mararamiro akaenzana emagetsi emapoka akasiyana. Pamusoro pemasero emagetsi, nucleic acids yemavirusi inoshandiswa sechirudziro, kunyange zvazvo dzimwe nucleic acids inogona kushanda se inducers of interferon. Pakati pezvikamu zvemasero e microbial anozivikanwa nemaitiro e-interferon, endotoxins emakiritriya ane gram-negative, pamwe ne lipopolysaccharides uye polysaccharides, kunyanya mapurogen, maitiro anonyanya kuita basa rinokosha. Interferon yevanhu inoshandiswa zvakasimba painobudiswa pamapapu eRNA-ane virusi, izvo zvakachengetedzwa zvakanaka pamusoro pekudzivirira kukanganisa kwe ribonucleases.

Kana iri iyo inonzi interferon, kusiyana neinozivikanwa inhibitor iyo inokanganisa zvirwere zvepabonde, inovabaya pamasero akaoma, achivapa kurwisana nehutachiona hwekubereka. Kuti interferon ikwanise kuratidza hutachiona hwehutachiona, masero ane utano anofanira kunge asina kunyatsogadziriswa kwema cell RNA uye mapuroteni esero.

Munguva pfupi yapfuura, "Interferon vanhu recombinant alpha 2" inosarudzwa senhengo inorwisa maitiro . Iyo nzira yehutachiona hwehutachiona inobatanidza nekugadzirwa kwenzira dzokuchengetedza mumasero asina utachiona asina kuonekwa. Izvi zvinoshandura nzvimbo yechinyorwa chemasero, izvo zvinodzivirira kupindira kwehutachiwana muchitokisi.

Izvo zvipenyu zve interferon zvinosanganisira zvisikwa zvakasiyana-siyana, izvo zvinoreva kusaratidza kusarudzwa kwebasa muhupenyu hwehukama hwavo. Semuenzaniso, interferon inogadzirwa nemasero emukoko embryo haikwanise kudzivirira makonzo kana mamwe mhuka, uye interferon inoberekwa neukokitiiti yevanhu haina basa mumhuka. Iyi pfuma haisi yakakwana uye, pane dzimwe nguva, interferon yeheterologous inogona kuratidza basa mune imwe mhuka.